-
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
NCT07351045 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Springfield
-
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
NCT07351058 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City
-
A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
NCT06143956 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Missouri: City of Saint Peters, Springfield
-
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
NCT07667803 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City, St Louis
-
A Phase 2 Study to Evaluate the Pharmacodynamics, Safety and Tolerability of BGE-102 in Participants With Obesity and Cardiovascular Risk Factors
NCT07656727 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City
-
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
NCT06672549 ·
Phase: Phase 3 ·
Ages: 6 Years to 17 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity
NCT07639021 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: City of Saint Peters
-
A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease
NCT06717698 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City
-
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
NCT07564414 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Chesterfield, St Louis
-
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
NCT07567001 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City, St Louis
-
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
NCT07654374 ·
Phase: Phase 3 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female)
· Missouri: Chesterfield, City of Saint Peters, Hazelwood, Springfield
-
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
NCT07282600 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Chesterfield, Springfield
-
A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight
NCT07369011 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
-
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
NCT07392190 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Chesterfield
-
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes
NCT07743450 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Columbia, St Louis
-
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
NCT07743463 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
-
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
NCT06672939 ·
Phase: Phase 3 ·
Ages: 12 Years to 17 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
NCT07153471 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: City of Saint Peters, Kansas City
-
A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)
NCT07575932 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Springfield
-
A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus
NCT07784725 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Jefferson City, Kansas City
-
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
NCT07142707 ·
Phase: Phase 1 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: Kansas City
-
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
NCT07589608 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Missouri: City of Saint Peters, Springfield
-
A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight
NCT07662122 ·
Phase: Phase 2 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· Missouri: City of Saint Peters, Springfield
-
A Trial to Evaluate Efficacy and Safety of Maridebart Cafraglutide in Adults Living With Elevated Liver Fat and Obesity or Overweight
NCT07441252 ·
Phase: Phase 2 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Missouri: Kansas City
-
AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
NCT07339423 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: City of Saint Peters
-
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
NCT07509307 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Springfield
-
Adapting and Testing a Novel Digital Health Tool (PREVENT) to Improve Health Behavior Counseling and Cardiovascular Health in Rural Primary Care Clinics
NCT06063564 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 64 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Advancing Biopsychosocial Care Training Initiative
NCT07049861 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 5 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
-
Alzheimer"s Imaging Biomarkers in Obesity
NCT05077579 ·
Phase: Not specified ·
Ages: 40 Years to 60 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity
NCT06745063 ·
Phase: Phase 2 ·
Ages: 30 Years to 60 Years ·
Sex: All (male and female)
· Missouri: Columbia
-
Brain Blood Flow and Lactate in Non-obese and Obese Subjects
NCT06791837 ·
Phase: Not specified ·
Ages: 18 Years to 45 Years ·
Sex: All (male and female)
· Missouri: Columbia
-
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
NCT05277558 ·
Phase: Not specified ·
Ages: 12 Years to 17 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older
NCT06636058 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 74 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Effect of Ketone Esters on Liver Fat Content and Metabolic Function
NCT07097506 ·
Phase: Phase 2 ·
Ages: 18 Years to 40 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Effects of Grape Consumption on the Immune-Gut Axis in Obesity
NCT07231484 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female)
· Missouri: Columbia
-
Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)
NCT07654361 ·
Phase: Phase 3 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female)
· Missouri: Chesterfield, Hazelwood, St Louis
-
Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity
NCT07497880 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Missouri: Jefferson City, Kansas City
-
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
NCT07037433 ·
Phase: Phase 3 ·
Ages: 45 Years to 99 Years ·
Sex: All (male and female)
· Missouri: City of Saint Peters, Kansas City, St Louis
-
Evaluation of a Novel Technology to Support Tailored Health Behavior Counseling in Rural Primary Care Clinics
NCT06397729 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 64 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Examining the Role of Executive Functioning in Family-Based Intensive Health Behavior and Lifestyle Treatment
NCT06969235 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 13 Years to 17 Years ·
Sex: All (male and female)
· Missouri: Columbia
-
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)
NCT07684235 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Missouri: Kansas City
-
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)
NCT07684144 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Missouri: Kansas City
-
Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity
NCT07091500 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 75 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Growth Hormone Resistance of Beta-cells A
NCT06571487 ·
Phase: Not specified ·
Ages: 18 Years to 45 Years ·
Sex: Female
· Missouri: Columbia
-
Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes
NCT06571500 ·
Phase: Not specified ·
Ages: 18 Years to 59 Years ·
Sex: All (male and female)
· Missouri: Columbia
-
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
NCT06335771 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Missouri: Columbia
-
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
NCT06571474 ·
Phase: Not specified ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Missouri: Columbia
-
Impact GLP-1 Agonists Following Bariatric
NCT06132477 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Columbia
-
Liver Adiposity Effects on Pediatric Statin
NCT04903223 ·
Phase: Phase 1 ·
Ages: 8 Years to 21 Years ·
Sex: All (male and female)
· Missouri: Kansas City
-
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
NCT07037459 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Missouri: Kansas City
-
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
NCT06937086 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
NCT06937099 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Phentermine's Impact on Treatment in Teens
NCT07282340 ·
Phase: Phase 2 ·
Ages: 12 Years to 17 Years ·
Sex: All (male and female)
· Missouri: Kansas City
-
Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation
NCT07607730 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 13 Years to 17 Years ·
Sex: All (male and female)
· Missouri: Kansas City
-
Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight
NCT07770841 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: City of Saint Peters
-
Role of KATP Channel Loss in Type 2 Diabetes
NCT06830096 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
NCT07083557 ·
Phase: Not specified ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Missouri: Columbia
-
Routine Validation and Reproducibility Testing of Laboratory Measures and Research Techniques Used for Metabolism Research (VAL)
NCT06286761 ·
Phase: Not specified ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Missouri: Columbia
-
Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
NCT07752979 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Missouri: City of Saint Peters
-
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
NCT05219799 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 45 Years ·
Sex: All (male and female)
· Missouri: Columbia
-
Small Extracellular Vesicles and Insulin Action
NCT05933707 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 25 Years to 55 Years ·
Sex: All (male and female)
· Missouri: St Louis
-
Social Determinants and a Diabetes Prevention Program Tailored for African Americans
NCT05301413 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City
-
Uterine Preservation Via Lifestyle Transformation
NCT05903131 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Female
· Missouri: St Louis