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A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
NCT07351045 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: West Chester
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A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
NCT07351058 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
NCT07667803 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: DuBois, Newport, Philadelphia
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A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
NCT06672549 ·
Phase: Phase 3 ·
Ages: 6 Years to 17 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity
NCT07639021 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
NCT07253285 ·
Phase: Phase 3 ·
Ages: 8 Years to 18 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
NCT07564414 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Beaver, Hatboro, Philadelphia
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A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
NCT07567001 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Camp Hill, Chambersburg, Doylestown, Lancaster
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A Self-Guided Mobile Intervention for Adults With Binge Eating and Obesity
NCT06817863 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
NCT07654374 ·
Phase: Phase 3 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
NCT07282600 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh, Uniontown
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A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
NCT07321886 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Uniontown
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A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
NCT07392190 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
NCT06897475 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Pennsylvania: Scottdale
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A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes
NCT07743450 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia, Pittsburgh
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A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
NCT07743463 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia, Pittsburgh
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A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
NCT06672939 ·
Phase: Phase 3 ·
Ages: 12 Years to 17 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
NCT07153471 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Altoona
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A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight
NCT07202884 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Female
· Pennsylvania: Erie, Philadelphia
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A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)
NCT07575932 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh, Uniontown
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A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus
NCT07784725 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia, Smithfield
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A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program
NCT05748158 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 25 Years to 59 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)
NCT06857942 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Plymouth Meeting
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A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
NCT07477704 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Duncansville
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A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
NCT06760546 ·
Phase: Phase 3 ·
Ages: 4 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
NCT07503210 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
NCT07339423 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
NCT07571005 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: DuBois
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AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
NCT07571109 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: DuBois
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An Acceptance-Based Healthy Lifestyle Intervention for Diverse Adolescents
NCT06147973 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 14 Years to 19 Years ·
Sex: Female
· Pennsylvania: Philadelphia
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Biobehavioral Reward Responses Associated With Consumption of Nutritionally Diverse Ultra-Processed Foods
NCT05437809 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
NCT05277558 ·
Phase: Not specified ·
Ages: 12 Years to 17 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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Brief Behavioral Sleep Intervention for Obesity Prevention in Primary Care
NCT06810557 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 6 Years to 11 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
NCT05082519 ·
Phase: Phase 2 ·
Ages: 7 Years to 25 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
NCT06482853 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Pennsylvania: Hershey
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Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)
NCT07654361 ·
Phase: Phase 3 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
NCT07353931 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Plymouth Meeting
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Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity
NCT06299891 ·
Phase: Phase 2 ·
Ages: 6 Years to 28 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)
NCT07575399 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Pennsylvania: Duncansville
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Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
NCT07037433 ·
Phase: Phase 3 ·
Ages: 45 Years to 99 Years ·
Sex: All (male and female)
· Pennsylvania: Beaver, Camp Hill, Horsham
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Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)
NCT07684235 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Pennsylvania: Newport
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Fast In-Bed Tracking (FIT) System Lifestyle Intervention is a Clinical Trial of a Bed Scale Device. Overweight Wheelchair Users Will Complete a Weight Loss Program, Half Get Scales at Baseline, Half at Month 6 Those Who Receive the Bed Scales at Baseline Are Expected to Have Increased Weight Loss
NCT07141342 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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Feasibility of Semaglutide in Advanced Lung Disease
NCT05746039 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Food Genetics Behavior Study
NCT05783765 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 5 Years to 7 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Food for Thought: Executive Functioning Around Eating Among Children
NCT06108128 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 4 Years to 6 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Healthy Mom Zone Gestational Weight Gain Management Intervention 2.0
NCT05807594 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 45 Years ·
Sex: Female
· Pennsylvania: University Park
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Increasing Food Literacy in Preschoolers to Reduce Obesity Risk
NCT05977348 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 3 Years to 6 Years ·
Sex: All (male and female)
· Pennsylvania: University Park
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Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
NCT05124808 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 45 Years ·
Sex: Female
· Pennsylvania: Pittsburgh
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Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
NCT07037459 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Pennsylvania: Horsham, Pittsburgh
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Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
NCT06937086 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
NCT06937099 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Monitoring Eating Across Locations (MEAL) - Timing, Intake, and Mealtime Evaluation (TIME)
NCT07095166 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 6 Years to 9 Years ·
Sex: All (male and female)
· Pennsylvania: State College
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Nurturing Needs Study: Parenting Food Motivated Children
NCT06111040 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 4 Years to 5 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Optimizing a Mobile Health Platform for Sleep Promotion and Obesity Prevention in Children
NCT05703347 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 8 Years to 12 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Pharmacogenetics of Response to GLP1R Agonists
NCT05071898 ·
Phase: Phase 1 ·
Ages: 18 Years to 89 Years ·
Sex: All (male and female)
· Pennsylvania: Lancaster
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Pregnancy 24/7 Offspring Study
NCT07172880 ·
Phase: Not specified ·
Ages: 0 Years to 47 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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Probiotics and Gut Health
NCT03418857 ·
Phase: Phase 1, Phase 2 ·
Ages: 55 Years to 75 Years ·
Sex: All (male and female)
· Pennsylvania: University Park
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RemI for Post-Bariatric Surgery Weight Regain
NCT06292936 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight
NCT07770841 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Resilience to the Effects of Advertising in Children
NCT05073185 ·
Phase: Not specified ·
Ages: 7 Years to 9 Years ·
Sex: All (male and female)
· Pennsylvania: University Park
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The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication
NCT07652333 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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Weight Bias Reducation Intervention With Nursing Students Using Simulation: The BRAVE Study
NCT07334470 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 35 Years ·
Sex: All (male and female)
· Pennsylvania: Villanova