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A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
NCT07351045 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Gurnee, Schaumburg, Skokie
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A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
NCT06143956 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Illinois: Chicago, Skokie
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A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
NCT07667803 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Melrose Park
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A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
NCT06672549 ·
Phase: Phase 3 ·
Ages: 6 Years to 17 Years ·
Sex: All (male and female)
· Illinois: Chicago
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A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity
NCT07639021 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease
NCT06717698 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Skokie
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A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
NCT07564414 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago, Gillespie, Gurnee, Skokie
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A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
NCT07567001 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago, Hazel Crest, Orland Park, Peoria
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A Study of ABBV-295 Subcutaneous Injections to Assess Adverse Events and Pharmacokinetics in Adult Participants With Obesity
NCT07291232 ·
Phase: Phase 1 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Illinois: Grayslake
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A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
NCT07282600 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Skokie
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A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
NCT07392190 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes
NCT07743450 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Schaumburg
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A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
NCT07743463 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Schaumburg
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A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
NCT06672939 ·
Phase: Phase 3 ·
Ages: 12 Years to 17 Years ·
Sex: All (male and female)
· Illinois: Chicago
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A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
NCT07153471 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)
NCT07575932 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Morton, Naperville
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A Study of Pitolisant in Patients With Prader-Willi Syndrome
NCT06366464 ·
Phase: Phase 3 ·
Ages: 6 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
NCT06239116 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Years to 65 Years ·
Sex: All (male and female)
· Illinois: Chicago
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A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
NCT06439277 ·
Phase: Phase 3 ·
Ages: 12 Years to 17 Years ·
Sex: All (male and female)
· Illinois: Chicago
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A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus
NCT07784725 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Champaign, Chicago
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A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)
NCT06864026 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago, Schaumburg, Skokie, Willowbrook
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A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
NCT07589608 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Illinois: Chicago
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A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity
NCT07595549 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago, Evanston, Skokie
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A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
NCT06760546 ·
Phase: Phase 3 ·
Ages: 4 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
NCT07503210 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Skokie
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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
NCT07339423 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Skokie
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AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
NCT07571005 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
NCT07571109 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
NCT07509307 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Gurnee, Skokie
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Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity
NCT05125822 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 11 Years to 15 Years ·
Sex: All (male and female)
· Illinois: Chicago
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Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.
NCT07566325 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 21 Years to 74 Years ·
Sex: All (male and female)
· Illinois: Chicago
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BRIDGE & Friends Trial
NCT07798557 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 79 Years ·
Sex: All (male and female)
· Illinois: Chicago
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Better Lifestyle Counseling for African American Women During Pregnancy
NCT05234125 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 40 Years ·
Sex: Female
· Illinois: Chicago
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Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
NCT05082519 ·
Phase: Phase 2 ·
Ages: 7 Years to 25 Years ·
Sex: All (male and female)
· Illinois: Chicago
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Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients
NCT06466161 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Female
· Illinois: Chicago
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DNA Methylation and Vascular Function
NCT03527420 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 50 Years ·
Sex: All (male and female)
· Illinois: Chicago
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Dietary Supplementation on Fat Oxidation
NCT06548048 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 50 Years ·
Sex: Female
· Illinois: Addison
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Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older
NCT06636058 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 74 Years ·
Sex: All (male and female)
· Illinois: Chicago
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EAT: A Reliable Eating Assessment Technology for Free-living Individuals
NCT06118528 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)
NCT07654361 ·
Phase: Phase 3 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female)
· Illinois: Chicago
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Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
NCT07353931 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity
NCT07497880 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Illinois: Chicago, Skokie
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Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes
NCT07284979 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago, Skokie
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Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
NCT07284901 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Skokie, Springfield
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Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
NCT07284875 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Springfield
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Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)
NCT07575399 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Illinois: Skokie
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Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
NCT07037433 ·
Phase: Phase 3 ·
Ages: 45 Years to 99 Years ·
Sex: All (male and female)
· Illinois: Arlington Heights, Chicago, Oak Brook, Springfield
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Exercise and Protein Efficiency in T2D
NCT07477067 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 65 Years and older ·
Sex: All (male and female)
· Illinois: Urbana
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Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
NCT05732623 ·
Phase: Not specified ·
Ages: 18 Years to 49 Years ·
Sex: All (male and female)
· Illinois: Chicago
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Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)
NCT07684235 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Illinois: Chicago, Skokie
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FIM+DASH: Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control
NCT07332741 ·
Phase: Phase 2 ·
Ages: No age limits stated ·
Sex: All (male and female)
· Illinois: Chicago
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Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention
NCT06390345 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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GI Oxalate Absorption
NCT05356000 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Illinois: Chicago
-
International Rapid-onset Obesity With Hypothalamic Dysfunction, Hypoventilation & Autonomic Dysregulation (ROHHAD) Registry
NCT03135730 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Illinois: Chicago
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Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
NCT07037459 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Illinois: Hazel Crest
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Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
NCT06937086 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Illinois: Chicago
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Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
NCT06937099 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Illinois: Chicago
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PRImary Care Strategies for Weight Management (PRISM) Study
NCT07288294 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists
NCT07207148 ·
Phase: Not specified ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Illinois: Chicago
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Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
NCT05918575 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago, Winfield
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Predictors of Behavioral Obesity Treatment Outcomes
NCT05326477 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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Preparing FIM-BCS - A Lifestyle Modification for African-American Breast Cancer Survivors
NCT06504914 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 99 Years ·
Sex: Female
· Illinois: Chicago
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Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss
NCT04228978 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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Randomized Control Trial of Sleeve Gastrectomy With Tirzepatide in Maximizing Weight Loss
NCT06734273 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Illinois: Chicago
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RemI for Post-Bariatric Surgery Weight Regain
NCT06292936 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Illinois: Chicago
-
Role of Adiposomes in Endothelial Dysfunction
NCT05199454 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 50 Years ·
Sex: All (male and female)
· Illinois: Chicago
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Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors
NCT05687604 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Illinois: Chicago
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Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation
NCT06499857 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Illinois: Chicago
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Stable Isotopes- Adults With Obesity
NCT07020741 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 19 Years to 59 Years ·
Sex: All (male and female)
· Illinois: Urbana
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Study of Nutrition and Exercise in Adults Hospitalized for Treatment of Acute Lymphoblastic Leukemia (ALL)
NCT06785324 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 50 Years ·
Sex: All (male and female)
· Illinois: Chicago
-
Time-restricted Eating Among Pregnant Females With Severe Obesity
NCT06477120 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 44 Years ·
Sex: Female
· Illinois: Chicago