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A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
NCT07351058 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Morehead City, Winston-Salem
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A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
NCT06143956 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· North Carolina: Greensboro, Monroe, Morehead City, New Bern
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A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
NCT07667803 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Greensboro, Raleigh, Rocky Mount, Statesville
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A Mobile Intervention to Reduce Pain and Improve Health-III
NCT06623669 ·
Phase: Phase 2 ·
Ages: 65 Years and older ·
Sex: All (male and female)
· North Carolina: Winston-Salem
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A Phase 2A Clinical Trial to Assess the Safety and Tolerability of ERX1000 in Men and Women for the Treatment of Obesity.
NCT07570758 ·
Phase: Phase 2 ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female)
· North Carolina: Monroe
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A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
NCT06672549 ·
Phase: Phase 3 ·
Ages: 6 Years to 17 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill, Durham, Morehead City
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A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity
NCT07639021 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Wilmington
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A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease
NCT06717698 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Morehead City, Winston-Salem
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A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
NCT07481630 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Wilmington
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A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
NCT07564414 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Greensboro, Greenville, Morehead City, Statesville
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A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
NCT07567001 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Apex, Concord, Durham, Greenville
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A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
NCT07654374 ·
Phase: Phase 3 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female)
· North Carolina: Charlotte, Durham, Fayetteville, Morehead City
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A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
NCT07282600 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Greensboro, Morehead City, Wilmington
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A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
NCT07321886 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Monroe
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A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
NCT07392190 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Chapel Hill, Greensboro, Morehead City, Wilmington
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A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
NCT06897475 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· North Carolina: Morehead City, Shelby
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A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes
NCT07743450 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Charlotte, Durham, Greenville, Morehead City
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A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
NCT07743463 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Charlotte, Greenville, Morehead City, Raleigh
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A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
NCT06672939 ·
Phase: Phase 3 ·
Ages: 12 Years to 17 Years ·
Sex: All (male and female)
· North Carolina: Morehead City
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A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
NCT07153471 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Shelby
-
A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)
NCT07575932 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Charlotte, Monroe, Statesville, Wilmington
-
A Study of Pitolisant in Patients With Prader-Willi Syndrome
NCT06366464 ·
Phase: Phase 3 ·
Ages: 6 Years and older ·
Sex: All (male and female)
· North Carolina: Morrisville
-
A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus
NCT07784725 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Statesville
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A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)
NCT06864026 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Salisbury
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A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
NCT07589608 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· North Carolina: Greensboro, Monroe, Morehead City, New Bern
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A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)
NCT06857942 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Cary, Huntersville
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A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity
NCT07595549 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Greensboro, Wilmington
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A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
NCT07477704 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· North Carolina: Durham, Wilmington
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A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight
NCT07662122 ·
Phase: Phase 2 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· North Carolina: Morehead City, Wilmington
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AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
NCT07503210 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Greensboro, Wilmington
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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
NCT07339423 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Chapel Hill, Greensboro, Wilmington
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AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
NCT07509307 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Statesville
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Ablation Registry (Combined Gastric Mucosal Ablation With Endoscopic Sleeve Gastroplasty for Weight Loss)
NCT06420700 ·
Phase: Not specified ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· North Carolina: Cary
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Breastfeeding Intervention to Prevent Obesity Among Children
NCT06921382 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 5 Days and older ·
Sex: All (male and female)
· North Carolina: Greensboro
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Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
NCT05082519 ·
Phase: Phase 2 ·
Ages: 7 Years to 25 Years ·
Sex: All (male and female)
· North Carolina: Charlotte
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Comparing the Effects of Front-of-Package Labeling Schemes in Indonesia
NCT07526584 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Concentration of n-3 PUFA Monohydroxylated Derivatives in Adults With Obesity After n-3 PUFA Supplementation.
NCT06991296 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 45 Years to 60 Years ·
Sex: All (male and female)
· North Carolina: Kannapolis
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Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)
NCT07654361 ·
Phase: Phase 3 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female)
· North Carolina: Charlotte, Durham, Fayetteville, New Bern
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Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes
NCT07284979 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Morehead City, Morrisville
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Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
NCT07284901 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Greensboro, Monroe, Morehead City, Morrisville
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Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
NCT07284875 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Morehead City
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Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)
NCT07575399 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· North Carolina: Morehead City, Raleigh, Wilmington
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Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
NCT07037433 ·
Phase: Phase 3 ·
Ages: 45 Years to 99 Years ·
Sex: All (male and female)
· North Carolina: Charlotte, Durham, Greensboro, Monroe
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Evaluation of Child Care Staff Weight Management Program
NCT05656807 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 2 Years and older ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events
NCT07607587 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Monroe, Wilmington
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Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)
NCT07684235 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· North Carolina: Hickory, Shelby
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Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)
NCT07684144 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· North Carolina: Morehead City
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FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)
NCT06724406 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Fundus Ablation Registry (Gastric Fundus Mucosal Ablation for Weight Loss)
NCT06428617 ·
Phase: Not specified ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· North Carolina: Cary
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Healthy Living Anson Study
NCT07126587 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome
NCT07296861 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: No age limits stated ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Inspiratory Pulmonary Rehabilitation for Children With Obesity and Asthma
NCT05608668 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 8 Years to 17 Years ·
Sex: All (male and female)
· North Carolina: Durham
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Interscalene vs Phrenic-sparing Blocks in Obesity and Effect of Maximum Inspiratory Pressure
NCT07216820 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
NCT04328337 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 45 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Investigating the Impact of Obesity on Pubertal Development in Girls
NCT02583646 ·
Phase: Not specified ·
Ages: 8 Years to 14 Years ·
Sex: Female
· North Carolina: Research Triangle Park
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MAINTAIN (Mucosal AblatIoN Therapy After INcretins)
NCT06734312 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 21 Years to 65 Years ·
Sex: All (male and female)
· North Carolina: Cary
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Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy
NCT07226765 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· North Carolina: Monroe
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Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
NCT07225686 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· North Carolina: Monroe
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Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
NCT07037459 ·
Phase: Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· North Carolina: Asheville, Durham, Lenoir, Statesville
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Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)
NCT05945355 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 6 Years to 17 Years ·
Sex: All (male and female)
· North Carolina: Durham
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Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis
NCT04320264 ·
Phase: Not specified ·
Ages: 18 Years to 50 Years ·
Sex: All (male and female)
· North Carolina: Greenville
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Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
NCT06937086 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· North Carolina: Fayetteville
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Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
NCT06937099 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· North Carolina: Fayetteville
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NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks
NCT05674799 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 39 Years ·
Sex: Female
· North Carolina: Winston-Salem
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Nutrition and Obesity in Under-Represented Populations: Food Insecurity Research to Advance Science and Improve Health
NCT06116422 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 12 Months to 24 Months ·
Sex: All (male and female)
· North Carolina: Durham
-
ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer
NCT05542407 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: Female
· North Carolina: Chapel Hill
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Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults
NCT06044571 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 65 Years to 85 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
NCT04752293 ·
Phase: Not specified ·
Ages: 7 Years to 18 Years ·
Sex: All (male and female)
· North Carolina: Winston-Salem
-
Physical Activity and Community EmPOWERment Project
NCT06740162 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Predicting Appendicular Lean and Fat Mass With Bioelectrical Impedance Analysis Among Adult Patients With Obesity.
NCT06545435 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Chapel Hill
-
Pregnancy Exercise Mode Effect on Childhood Obesity
NCT04805502 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 45 Years ·
Sex: Female
· North Carolina: Greenville
-
Preventing Type 2 Diabetes in Black Emergent Adult
NCT06848244 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 25 Years ·
Sex: Female
· North Carolina: Chapel Hill
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Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss
NCT07446998 ·
Phase: Phase 2 ·
Ages: 65 Years to 100 Years ·
Sex: All (male and female)
· North Carolina: Fayetteville
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REvision of VSG with Ablation of the Mucosa Procedure
NCT06671119 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 22 Years to 60 Years ·
Sex: All (male and female)
· North Carolina: Cary
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Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
NCT07752979 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· North Carolina: Greensboro, Monroe, Morehead City, New Bern
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Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes
NCT03885245 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· North Carolina: Durham
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The Osteoarthritis Prevention Study
NCT05946044 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years and older ·
Sex: Female
· North Carolina: Chapel Hill, Winston-Salem
-
Tirzepatide in Obesity-Driven Endometrial Cancer
NCT07065552 ·
Phase: Early Phase 1 ·
Ages: 18 Years and older ·
Sex: Female
· North Carolina: Chapel Hill
-
Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors
NCT06848491 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 39 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill